- "Another brother? Thought I killed all of you. I wondered who was behind all of this; trying to kill me with a lesser hitman."
- ―Agent 47
Agent 17 (also known as "Mr. 17") was Dr. Otto Ort-Meyer's first successful cloned assassin, and is the predecessor to Agent 47. He is very similar to Agent 47 (and in turn, the No. 48's) in appearance, with the difference that he wears black sunglasses and an orange colored tie.
While Agent 17 was a healthy clone and a perfectly capable assassin, Ort-Meyer found out, upon upbringing and training him, that he did not possess any enhanced strength or endurance over that of an average human.
He also appeared to be incapable of independent thought, and therefore Ort-Meyer regarded him as a disappointment, and eventually had him locked away deep within the asylum.
Years later, he was found by Sergei Zavorotko and the Mystery Man, when they were searching the facility sometime after Ort-Meyer's death.
Zavorotko found Agent 17's skills useful, and lent him out to Deewana Ji to whom he had sold a nuclear device. Deewana's cult would, however, with help from Agent 17, trick Zavorotko and steal the warheads in his possession. After Agent 47 killed Deewana, Agent 17 tried to kill him by confronting Agent 47 near his extraction point and leading him into a trap, but failed to do so. Agent 17 would then go back to serve Zavorotko, who eventually sent him out to kill Agent 47.
During St. Petersburg Revisited, Agent 47 was requested to kill Zavorotko on order from the United Nations. However, Zavorotko had anticipated it and sent Agent 17 there. In the end, Agent 17 ended up being killed by Agent 47, who remarked on how he thought he had killed all of his "brothers".