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Hayamoto inhabits a six-story Katsuyama-jō castle which is guarded by highly-trained shinobi ninjas, snipers and the latest electronic security measures. His income stems from pornography, smuggling of goods, narcotics (primarily amphetamines) and arms dealing which is his favourite source of income.
Given this penchant for weaponry, Hayamoto spends a lot of time with them, even acquiring a missile guidance system. This has infuriated the Agency's client, who wants Hayamoto eliminated and the guidance system recovered.
For this to happen, Agent 47 must first kill his son Masahiro Hayamoto Jr. at his remote private estate and implant a transmitter in his corpse. After Hayamoto's guards bring his son's remains to his home, 47 infiltrates the caste and kills Hayamoto.
47 infiltrates Katsuyama Castle and kills Hayamoto himself (with help from Mei-Ling) in his own room on the castle's top floor. After stealing an experimental missile guidance system from Hayamoto's private museum in the castle's basement, 47 escapes the castle.
- If he sees 47, he won't retaliate and will instead flee into the museum in the basement to pick the missile guidance system and then try to escape in his helicopter, if he succeeds, the mission fails. However, if 47 wounds him enough he will stop fleeing and then attack 47 with his Katana.